
Disclosure
This page is published by Vitro and is an advertisement for Vitro EGF NAD+ Firming Serum. The story is told in the first person, and the names and details in it are illustrative. It is general information about cosmetic skincare, not medical advice, and results vary from person to person. If you have a skin condition, check with your dermatologist before trying something new.
The percentages quoted come from Vitro's consumer self-assessment study. Prices, offers and shipping times are those shown on tryvitro.com at the time of writing and may change.
At my son's engagement dinner the photographer kept asking me to push my chin forward. Then she sent the photos.
The photographer sent 640 photos from the wedding. I'm in 212 of them, and I like every one. Another mother in the family group chat told me what she'd started eight weeks before her own daughter's wedding. Three drops, morning and night. That's why a small red bottle now sits next to my toothbrush, and why I stood in the front row for the family portraits.

I'm fifty-six, and that August my son Daniel was ten weeks away from marrying a lovely girl named Priya. I was the mother of the groom. I'd bought the dress back in March, dusty blue with sheer sleeves, and I'd been looking forward to that day for a year. Then the photos arrived.
For most of my forties and fifties I didn't look at my face much. I run the front desk at a dental office, I raised two boys, and my routine for years was hand soap, whatever moisturizer was on sale, and sunscreen when I remembered. I never minded getting older. I still don't, mostly.
At the engagement dinner in July the photographer kept quietly asking me to push my chin forward. "A little more. Little more." In August she emailed a preview of her favorite shots. There was one of me laughing at something Daniel said, taken from slightly below in the restaurant light. I zoomed in on my phone. My jaw had softened into my neck, there were lines fanning from my eyes into my hairline, and my neck looked like it belonged to someone ten years older. I put the phone face down on the counter.
My sister Ruth came over that evening and I showed her. She's two years older and has never been big on tact. "It's the angle," she said, then looked again. "Mostly the angle. Linda, you've washed your face with hand soap for twenty years. What did you think was going to happen?"
The hard part was that she had a point. I'd stopped looking closely years ago. The lines had arrived the way gray hair does, a few at a time while you're busy, and somewhere along the way I'd started standing at the back of group photos without ever deciding to. That's how it happens, I think. Nobody tells you. You just start picking the back row.
Then Priya's mother, Anjali, posted in the wedding group chat. Priya had set it up for both families in the spring, about thirty people sharing seating plans and arguing about the playlist. Anjali is fifty-eight, she'd been through all this two years earlier when her older daughter got married, and she answered a question nobody had asked.
"Advice from someone who hated her engagement photos last time," she wrote. "Whatever you're planning for the big day, hair, nails, skin, start eight weeks out."
I messaged her privately, a bit embarrassed, and it came out more honestly than I meant it to.
"Was that skin comment for me? I saw the engagement photos and nearly cried. I don't own a single serum. I don't even know what you'd start eight weeks out. Start what?"
She called me that evening. She'd clearly had this conversation before, because she went straight to the point.
"Same as me two years ago. I saw the proofs from Meera's engagement and my mother was looking back at me. I'd tried every cream in the drugstore. Then I started a firming serum every morning and every night, eight weeks before the wedding. Give it the eight weeks, then look at the photos. Then we can talk about hiding behind the bridesmaids."
The message in the group chat, and the phone call that followed

Anjali sent me a photo of the bottle on her bathroom shelf. Vitro EGF NAD+ Firming Serum, a small red bottle with a white dropper. Three or four drops on the face and neck in the morning, the same again at night.
Then she told me why she'd picked it. NAD+ is the headline ingredient, she said, right there on the label under its long name, with collagen extract and glycerin alongside it. Her skin had stopped looking thin and crepey, and the lines around her eyes had softened enough that she'd stopped noticing them.
"This is what I used before Meera's wedding," she said. "It's the one thing I've kept buying. It goes on light, it sinks straight in, and you see it where the camera looks, along the jaw and around the eyes. It's three drops, and it works alongside the rest of your skincare, so you don't have to give up anything you already use. Eight weeks of three drops isn't much to ask."
I laughed. "Anjali, it's a bottle the size of my thumb. What are three drops going to do about my neck?"
"Morning and night, after you wash your face," she said. "That's all I'm asking. By the third week you won't need me to talk you into it."
I stayed doubtful. I'd bought a few expensive jars over the years and never noticed a thing, and I couldn't see how a few drops would be any different.
But Anjali had already sent me the link, and that evening, with my husband Rob watching the ballgame next to me, I ordered the two-bottle set anyway.
The first mornings, when it was just three drops

The package took about two weeks to arrive, which left me exactly eight. Inside were two small red bottles with white droppers, and the free face mask, which I put straight in a drawer for the morning of the wedding.
Three to four drops on clean skin, face and neck, massaged in until they're gone. I put them on after my shower while the coffee brewed. The serum went on light and sank in before I'd put the dropper back.
Anjali had said it would take less time than finding my reading glasses. She was right. I timed it at under a minute.
That was the morning done, before the coffee was. My skin felt comfortable, with no sting and no tightness.
That night, the same. Three drops before bed, and again the next morning.
By day three I was doing it without thinking. Rob noticed before I did, because the bottle had moved from the cabinet to the edge of the sink.
Three drops in the morning, three at night, and for once a routine I didn't have to talk myself into.
I sent Anjali a selfie with the bottle: "Is that honestly all there is to it? Two days in and it already feels normal."
She wrote back: "That's the whole point. It's made for women our age who are tired of complicated routines. That's why in two years I haven't skipped a night."
I caught myself looking in the mirror a little longer while I brushed my teeth. The power of suggestion, probably.
But I felt a bit more hopeful about the wedding, in a quiet, cautious way.
And that felt real to me.
It was only week one, and I wasn't expecting miracles yet. My cheeks felt soft when I touched them, and they stayed that way past lunch, which they hadn't in years. And the dread I'd been carrying about the photos suddenly felt a little lighter.
I felt like someone who was actually going to enjoy her son's wedding.
And that was WEEK ONE.
What Anjali told me at week three

Around week three Ruth and I did our usual Sunday walk around the lake, and halfway around she stopped me to take a photo, which she never does. I looked at it in the car afterward and liked it. The lines around my eyes looked softer, and my skin had a bit of life to it in daylight. So I called Anjali and asked her to explain, properly this time, what I was putting on my face.
Her answer made me think about the drawer of half-used jars in my bathroom.
The advice everyone gives you after fifty
The usual advice for skin after fifty is drink more water, wear sunscreen and find a good moisturizer. I did two out of three, most days. My face felt fine until about four o'clock, then the dry, tired look came back, and the softness under my jaw stayed exactly where it was.
The other route is the department-store counter. Forty minutes on a stool, a bag of samples, a three-hundred-dollar cream and a printed card with ten steps on it. Some women love all that. I lasted four days.
So I went back and forth between the drugstore aisle and the beauty counter for years, and the thing I minded most, the softness along my jaw, never came up at either.
What the serum is actually for
Anjali put it to me like this:
"Most of the jars we buy are moisturizers. They keep your face comfortable for a few hours, which is what they're made for. Very few are made with firmness in mind."
Vitro is a firming serum built around NAD+, which you'll find on the label as nicotinamide adenine dinucleotide. Alongside it there's collagen extract, for skin that looks firmer, and glycerin. It goes on light and sinks in fast, face and neck.
Glycerin is one of the best-known moisture-holders in skincare. It draws water into the skin and holds it there, so skin looks plumper and dewier, and the dry, papery look by evening eases off.
The idea is steady, everyday use. Morning and night, a little at a time, and the results build on each other the longer you keep it up.
A few drops on clean skin, massaged in until they're gone. That's the routine.
Two minutes a day, split between the morning and the night. That's the whole commitment.
It's made for the things the photos actually show: the look of fine lines, firmness and glow.
What's actually in the bottle
Here's what's on the label, and what women in Vitro's study reported:
NAD+ (nicotinamide adenine dinucleotide): the headline ingredient, the one the whole serum is built around. In Vitro's consumer self-assessment study, users of the serum reported a 29.4% visible reduction in fine lines and wrinkles after two weeks
Collagen extract: the second name on the front of the bottle, there for the bouncy, firm look skin loses a little more of every year. In the same study, users reported a 33.1% improvement in skin elasticity and firmness after two weeks, which counts for a lot when the camera is looking up at your jaw
Glycerin, for hydration. Glycerin draws water into the skin and holds it there, and users reported a 36.8% improvement in skin hydration after the very first application. The rest of the list is short: water, 1,2-hexanediol, carbomer and arginine. It works as the last step of your routine or layered with other serums
That's the whole routine: three to four drops, twice a day, face and neck.
The Saturday in the salon chair I didn't see coming

I was about six weeks in, and it was an ordinary Saturday, the makeup trial for the wedding at a salon in town, the appointment I'd been dreading since August.
Same face, same nerves, same habit of tucking my chin whenever anyone points a camera my way. My skin felt smooth under my fingers, though, and I noticed I wasn't bracing.
I hadn't even thought about which side of my face to give the mirror.
Three drops after my shower, coffee, out the door. That was the whole morning routine, and I'd left the turtleneck in the closet.
That's when Tess, the makeup artist, turned my face toward the window and stopped.
She'd done my face for the engagement dinner back in July, so she knew what she'd been working with. This time she kept stopping to look at my skin under the light.
"What have you been doing?" she said. "Your skin's completely different from July. I'm hardly putting anything on you."
I laughed, and it caught in my throat for a second.
That was the moment it landed.
I'd sat through the whole trial without once checking the mirror for my jawline, and I hadn't even noticed. I'd been tucking my chin and planning to stand behind someone taller for so long that I nearly missed the moment I stopped.
Then the woman in the next chair joined in.
"Sorry, I couldn't help hearing," she said. Someone's aunt, by the sound of it. "What are you using?"
"It's a serum called Vitro. Three drops, morning and night. My son's future mother-in-law told me about it."
She asked me to spell it and wrote it on the back of her appointment card. One remark in a salon chair, and a stranger wanted to know what I was doing to my face.
"Honestly, you look like you've had a month off," Tess said, reaching for her brushes.
I didn't say anything for a second. I wanted to enjoy it.
Afterward I sat in the salon parking lot for a minute and looked at my jaw in the rearview mirror in full afternoon sun. For the first time in years I wasn't working out which angle to hide.
I wanted the photographer to take my picture.
The eight weeks I marked on the calendar

I did three drops every morning and every night, and the change came week by week, right up to the date I'd circled on the kitchen calendar.
Day 1: Three drops after my shower, three before bed. It went on light and sank in fast, with no sting or tightness. Nothing dramatic yet, and I didn't expect it to be.
Weeks 1-2: My skin felt softer and stayed comfortable all day. Anjali had told me to be patient about the rest. If anything, I stopped dabbing hand cream on my dry cheeks at four o'clock.
Weeks 3-4: The first changes I could actually see. The lines at the corners of my eyes looked softer in the bathroom light, and my skin had a bit of glow to it. A patient at work asked if I'd been on vacation, which nearly finished me off.
Weeks 5-8: This is when it really landed. I took a selfie from below on purpose, the exact angle I'd been avoiding since August, and kept it. The skin along my jaw and neck looked smoother, firmer, like the camera had stopped being something to dread.
The best part was the small things adding up. A photo I didn't delete here, a compliment from a stranger there. By the eighth week I had a camera roll I actually scrolled through.
Somewhere in there I stopped dreading the camera.
Nothing else about my routine changed. Same sink, same towel, one small bottle on the shelf, that's it. And for the first time in years I wasn't planning photos around my jawline.
Why almost nobody tells women our age this

This part still annoys me.
Most of what women our age hear about skin is about protecting it: sunscreen, water, a good night cream. Sensible stuff, and I still do all of it. Firmness barely comes up, even though it's the thing the camera picks up first.
If more women knew a few drops a day could visibly smooth and firm the skin the camera sees, I think most of us would have started years ago.
When did anyone last hand you something made for skin past fifty?
The big beauty brands sell what sells: heavy night creams, ten-step kits, the same jar bought again every month. A firming serum built around NAD+ is a much smaller corner of the market, and hardly anyone points you to it.
I'd ended up with a drawer full of half-used jars over the years. None of them changed a thing.
Vitro is one small bottle.
Three to four drops twice a day of NAD+, collagen extract and glycerin, for the look of fine lines, firmness and hydration all at once. I put mine on after my shower without thinking about it.
The women I know who use it have stayed with it.
It's sold online, direct from Vitro's own site. It has sold out more than once, too. Most people find Vitro because somebody told them, the way Anjali told me.
Anjali summed it up dryly on the phone: "Everyone has an opinion about your skin. Very few of them have tried anything for eight weeks straight."
Why I'd start eight weeks out

This was the line from Anjali that stuck with me:
"Your skin needs time," she said. "The earlier you start, the more you'll see on the day itself. Leave it to the last two weeks and you're cutting it close."
I'll say it straight.
It's three to four drops, twice a day. For me that's after my shower and before bed, and the rest of the day I don't think about it.
And the thing she said that really stuck: your skin doesn't change just because the date is getting closer.
Every week you put it off is another week nearer the big day with nothing to show for it. Another week of the same tired skin in the mirror.
And it doesn't take forever to feel the first of it. Many women notice softer, more hydrated skin within the first week. Visible changes in firmness, fine lines and radiance usually show up after two to four weeks of using it every day. But those weeks only start counting once you begin.
The results build the longer you use it, so give it the whole eight weeks if you can. It sounds like a long time. You keep telling yourself you'll deal with your skin eventually, and eventually another family photo goes in a frame with you angled behind somebody.
Believe me, I wish I'd started before the engagement dinner. I spent years buying jars, second-guessing and waiting for a better moment. For the skin I actually minded, I did nothing useful at all.
I don't get those years back. But the morning after the bottles arrived, I put on my first three drops.
And honestly: the sooner you order, the sooner the first drops go on.
Here's what happens if you keep putting it off:
In the next few weeks:
Your skin looks the way it does today, and you keep negotiating with the camera angle
Another jar of night cream joins the drawer
The weeks before your own big day tick past
The bundle you meant to try is still sitting in your cart
This time next year:
Your jaw and neck look the way they do now
You still pick the back row in group photos
A friend who started months ago tells you how easy it was
Another wedding, birthday or reunion comes around and you're still meaning to order
And now the part nobody likes to hear:
Every week you wait is another week with nothing new on your skin. The calendar runs either way. The only question is whether anything's changed by the time the photographer says "chin forward." Three drops, morning and night, and let it get on with the work.
The good news is you can order yours today.
That's exactly what Vitro is built for. NAD+ and collagen extract for the look of firmer, smoother skin, and glycerin for hydration you can feel from the first day. A few drops on clean skin, morning and night. For me it went from deleting every photo with my jaw in it to asking the photographer for one more.
Every day you use it, the results build a little more, while you get on with your life.
So let me put it plainly.
Ask yourself this: Do you want to spend the next eight weeks getting ready for the photos? Or look back next year and wish you'd started now?
And right now the sale is on, with a free Collagen Face Mask and free shipping on the two-bottle bundle. I don't know how long the sale runs.
I'm writing this because I wish someone had told me a year earlier, before the engagement dinner and the photo I turned face down on the counter.
The catch: buy it direct from Vitro
Vitro sells it online through its own website, and the brand says to buy it only there so you know you're getting the real thing.
The upside is that it's simple: Every order is fully tracked, and shipping is free on orders over $50. Allow about two days for processing and six to twelve business days for delivery, so order with a few weeks to spare before your own big day.
Anjali told me straight away to keep it simple and stay at it. Three to four drops on clean skin, morning and night, face and neck. Consistency is what does it. Skipping all week and then using twice as much on Sunday is like watering a plant once a month. A few drops every morning and every night, and the results build.
Anjali's sister put it well: she only realized how much it was doing when she ran out for two weeks and the dry, tired look crept back.
I keep a spare bottle in the cabinet now so I never run out. Anjali goes for the bigger bundle, three bottles, and gets a K-Beauty Balm and a face mask thrown in. That's the best-value option, and the two-bottle one is the most popular.
Here's the quick math. A single bottle is normally $79.99, and it's $39.99 in the current sale. I went with the two-bottle bundle, the most popular one, at $64.99 for both, which works out to about $32.50 a bottle, and it came with a free Collagen Face Mask and free shipping.

Smoother, firmer-looking skin, three drops at a time
NAD+ with collagen extract and glycerin, morning and night. Two bottles for $64.99 $159.98, with a free Collagen Face Mask and free shipping.
What customers are saying
Women on Vitro EGF NAD+ Firming Serum
Vitro's NAD+ Serum smoothed my crow's feet, plumped my eyes, and gave my skin a glow. I love how it absorbs instantly and starts working fast.
I started it six weeks before our 40th anniversary party. By about week three the lines around my eyes looked softer, and my neck looked smoother in the photos than it had in years. Three drops twice a day is the only routine I've ever kept.
I teach fourth grade, under fluorescent lights all day. By three o'clock my skin used to look dull and dry. After a couple of weeks it stayed soft all day, and a colleague asked what I'd changed. It fits right into my morning routine.
If you've read this far, circle your date and give yourself eight weeks
For years I stood at the back of photos and hoped I'd feel more like myself by the next one.
The photos I turned face down. The "you look great for your age" from everyone who meant well. The mornings I knew, without saying it, that my jaw had gone soft.
And then that Saturday in the salon chair. "What have you been doing? Your skin's completely different from July." Me sitting there, trying not to look too pleased. Here's the whole secret.
Three drops every morning and every night, while I got on with the wedding planning.
For a while I'd decided this was simply my face now, and photos were something to get through. I'd stopped expecting to like a picture of myself.
Eight weeks later I stood next to my son for the family portraits, and the photographer didn't have to say a word about my chin. I've ordered prints of every one.
- Choosing a selection results in a full page refresh.
- Opens in a new window.

Disclosure
This page is published by Vitro and is an advertisement for Vitro EGF NAD+ Firming Serum. The story is told in the first person, and the names and details in it are illustrative. It is general information about cosmetic skincare, not medical advice, and results vary from person to person. If you have a skin condition, check with your dermatologist before trying something new.
The percentages quoted come from Vitro's consumer self-assessment study. Prices, offers and shipping times are those shown on tryvitro.com at the time of writing and may change.
© 2026 Vitro. All rights reserved.
- Choosing a selection results in a full page refresh.
- Opens in a new window.
- Choosing a selection results in a full page refresh.
- Opens in a new window.
- Choosing a selection results in a full page refresh.
- Opens in a new window.