#1 Barrier Relief Cream
Dermatologist Inspired
Rated 4.9 Excellent | Over 50,000+ Sold
Selling out fast
High demand, restocking frequently
In Stock
FREE Shipping Over $50
30-Day Money-Back Guarantee
Refills every 30 days at purchased price
Skip, pause, or cancel anytime
Free items ship on first order only
Trusted by 50k+ customers
for clean, reliable support
30-Day Money Back Guarantee
Love your results within 30 days or get 100% of your money back.
What makes Vitro different?
Most barrier creams temporarily moisturize and nothing more. Vitro's 345 Relief Cream goes further. It combines three blemish-fighting actives, four nourishing essentials, and five soothing ingredients — including Niacinamide, Ceramide NP, Panthenol, Tea Tree Leaf Water, Centella Asiatica, Madecassoside, Resveratrol, Beta-Glucan, and dual-weight Hyaluronic Acid — in one lightweight gel-cream designed to actually calm, repair, and rebalance your skin over time. Clinically tested as non-comedogenic. No essential oils. No pore-clogging ingredients.
Key ingredients
Niacinamide — Helps brighten uneven skin tone, fade post-acne marks, minimize pore appearance, and calm redness. Government-certified brightening active in South Korea.
Ceramide NP — Bioidentical to the ceramides already in your skin. Strengthens and restores the moisture barrier to lock in hydration and protect against irritants.
Panthenol (Vitamin B5) — Draws moisture deep into the skin and locks it in. Soothes irritation, accelerates healing, and keeps the barrier supple with every use.
Tea Tree Leaf Water — Gently antimicrobial and purifying. Helps keep acne-prone skin clear without stripping or irritating the barrier.
Centella Asiatica and Centella Asiatica Leaf Water — Calms visible redness and inflammation on contact, stimulates collagen, and accelerates barrier repair.
Madecassoside — A purified active from Centella Asiatica clinically proven to calm and protect sensitive, reactive skin and accelerate healing.
Resveratrol — A potent antioxidant that fights environmental damage, brightens skin tone, and helps protect against future discoloration.
Beta-Glucan — A deeply calming, hydrating active that soothes sensitized skin, reduces redness, and reinforces the skin barrier.
Sodium Hyaluronate and Hydrolyzed Hyaluronic Acid — Two molecular weights of hyaluronic acid working at both the surface and cellular level for lasting, deep hydration.
Tocopherol (Vitamin E) — Protects the skin from oxidative stress and supports barrier health and long-term skin resilience.
Free from: Parabens, Sulfates, Fragrances, Essential Oils, Comedogenic Ingredients.
Will it work for my skin?
Your skin will feel calmer and more hydrated immediately after first use. With consistent use morning and evening, visible improvements in redness, texture, and overall skin comfort may become noticeable within 1 to 2 weeks. More significant changes to post-acne marks, tone, and barrier strength continue to build over 4 to 8 weeks.
How long until I see results?
Your skin will feel more hydrated and refreshed almost immediately after first use. With consistent use once or twice daily, improvements in smoothness, firmness, and overall texture may become noticeable within 1 to 2 weeks. More significant changes to fine lines, tone, and skin density continue to build over 4 to 8 weeks.
How do I use it?
Daily moisturizer:
As the final step of your skincare routine, scoop a small amount of cream into your palms, apply evenly over the face, and gently press into the skin until absorbed. Follow with SPF in the daytime.
Sandwich method with strong actives:
When using potentially irritating actives such as retinoids, apply a light layer of the 345 cream first to cushion the skin. Follow with your active treatment, then apply another layer of the 345 cream on top to seal in moisture and support the skin barrier.
For best results, use consistently morning and evening as part of your daily skincare routine.
Is it greasy or heavy?
Not at all. The gel-cream formula has a lightweight, fast-absorbing texture that melts into the skin without leaving a greasy or heavy finish. Most customers describe it as cooling and comfortable on contact, suitable for layering under makeup or SPF.
Can I wear it with makeup?
Yes. The formula absorbs cleanly and creates a smooth, non-greasy base that works well under makeup. Apply in the morning as the last skincare step, allow it to fully absorb, then apply your makeup or SPF on top.
Shipping, tracking, & returns
All orders ship from our US warehouse within 24 hours of being placed. Delivery typically takes 4 to 7 business days. Every order is covered by our 30-Day Money-Back Guarantee. If you are not completely satisfied with your results, contact us within 30 days for a full refund, no questions asked.
Calms Redness
Repairs Skin Barrier
Fades Post-Acne Marks
Deeply Hydrates
Soothes Irritation
Non-Comedogenic
Calms Redness
Repairs Skin Barrier
Fades Post-Acne Marks
Deeply Hydrates
Soothes Irritation
Non-Comedogenic
What Our Customers Are Saying:
Skin-Loving Ingredients
Clean, effective, and nourishing formulas your skin will thank you for
30-Day Money-Back Guarantee
Real People. Real Results.
Loved by 50,000+
Your barrier
was never broken.
It just needed the right formula.
Ten clinical Korean actives — Niacinamide, Ceramide NP, Panthenol, Tea Tree Leaf Water, Centella Asiatica, Madecassoside, Resveratrol, Beta-Glucan, dual-weight Hyaluronic Acid, and Tocopherol — delivered in a lightweight gel-cream that absorbs instantly and goes to work at the barrier level. Clinically tested as non-comedogenic. No essential oils. No fragrance. No pore-clogging ingredients. Calmer skin, faded post-acne marks, a stronger barrier, and a visibly clearer complexion. One cream. Press in and go.
Absorbs Instantly
Non-Comedogenic Tested
Korea-Certified Actives
No Essential Oils
Layers Under Makeup and SPF
Morning, Night, Daily Use
Your Skin Journey with Vitro:
FROM FIRST USE
Instant Calm
- ✔Redness and irritation visibly reduced on contact
- ✔Skin feels cooler, calmer, and more comfortable
- ✔Redness and irritation start to calm
- ✔Barrier feels supported and less reactive
- ✔Skin looks more settled and even from day one
WEEKS 2–4
Barrier Rebuilt
- ✔Skin barrier grows stronger and more resilient
- ✔Redness and sensitivity continue to reduce
- ✔Texture begins to smooth and refine
- ✔Post-acne marks start to lighten
- ✔Skin feels hydrated and balanced throughout the day
WEEKS 4–8
Marks Fade
- ✔Post-acne marks and dark spots visibly fade
- ✔Skin tone looks clearer and more even
- ✔Breakouts become less frequent and less severe
- ✔Texture keeps refining, rough patches soften
- ✔Skin feels balanced, comfortable, and resilient
WEEKS 8–12
Clear and Even
- ✔Skin tone is visibly clearer and more uniform
- ✔Post-acne marks and discoloration continue to fade
- ✔Barrier is noticeably stronger and less reactive
- ✔Skin looks brighter and healthier than in years
- ✔People start to notice
WEEK 20+
Full Transformation
- ✔Clear, calm, and even-toned skin that holds
- ✔Stronger resilience against breakouts and irritation
- ✔Deep hydration that lasts all day
- ✔ A healthy, naturally balanced glow
- ✔The complete transformation, and still building
30-Day Money-Back Guarantee
Korean-Formulated
Clinically Backed Actives
Fragrance-Free
Non-Comedogenic
Rebuilds Skin Barrier
30-Day Money-Back Guarantee
Korean-Formulated
Clinically Backed Actives
Fragrance-Free
Non-Comedogenic
Rebuilds Skin Barrier
30-Day Money-Back Guarantee
Vitro vs. Other Brands
30-Day Money-Back Guarantee
Repairs the Skin Barrier
Fades Post-Acne Marks
Non-Comedogenic Tested
Korea-Certified Actives
No Essential Oils
Other Brands
Sits On The Surface
Gone By Morning
One Mechanism Each
Unverified Claims
Clinic Visits Required
30-Day Money-Back Guarantee
FEEL THE DIFFERENCE
30-Day Risk-Free Trial
If you're not completely satisfied in your first 30 days, simply return your order for a full refund — no questions asked.
Frequently Asked Questions
Will it break me out or irritate sensitive skin
No. The formula is clinically tested as non-comedogenic, free from essential oils, and formulated without parabens, sulfates, or fragrance. The active ingredients, including Ceramide NP, Centella Asiatica, Madecassoside, and Beta-Glucan, are specifically chosen to support and calm the skin barrier rather than disrupt it. If you have highly reactive skin, patch test on the inner arm before full use.
Is it safe for long-term daily use
Yes. All active ingredients are clinically supported and formulated for daily use. Niacinamide, Panthenol, Ceramides, Centella Asiatica, and Hyaluronic Acid are all well-tolerated actives with strong long-term safety profiles. The cream is designed as a daily moisturizing step, morning and evening, with no requirement to cycle off.
Can I use it with my other skincare
Yes. Apply the cream as the final or second-to-last step in your routine, after any toners, serums, or treatments. It works especially well as a sandwich method around strong actives like retinoids — apply a layer before and after to protect the barrier. It is compatible with retinol, vitamin C, exfoliating acids, and SPF.
How often should I use it
Once or twice daily, morning and evening, for best results. Consistent daily use is what drives the cumulative improvements in barrier strength, redness reduction, and post-acne mark fading over time.
Can I buy Vitro in stores or on Amazon
Vitro is available exclusively at tryvitro.com. We do not sell through Amazon, retail stores, or third-party sites. Any listings you see elsewhere are unauthorized resellers and we cannot guarantee the authenticity or condition of those products.
Where do you ship, and are there duties
We ship from our US warehouse to addresses across the US. International shipping is available to select countries. Duties and import fees may apply depending on your country and are the responsibility of the buyer. Delivery within the US typically takes 4 to 7 business days.
What if it doesn't work for me?
We offer a 30-Day Money-Back Guarantee. If you are not completely satisfied within your first 30 days, contact our support team at support@tryvitro.com and we will issue a full refund, no questions asked. We want you to love your results, and if you don't we make it right.
How can I get in contact?
Email us at support@tryvitro.com. Our team is available Monday to Friday, 9AM to 5PM EST. We typically respond within 24 hours on business days.
Verified customer reviews
Rated 4.8/5.0 | Excellent
It feels lightweight but provides plenty of hydration, leaving my skin soft, smooth, and comfortable all day. It absorbs quickly without feeling greasy and works beautifully under makeup.
Azulayyy. • Verified Customer
This product is really lightweight on the skin and absorbs really quickly. I find it helps to soothe my skin and my acne heals faster.
Aj. • Verified Customer
I absolutely love this moisturizer. It absorbs fast and leaves my skin feeling really smooth. I appreciate that there's no heavy fragrance.
B. • Verified Customer
Good for pigmentation spots and sensitive skin. I have combination skin and it doesn't make my face look greasy. Will definitely purchase again.
Esra. • Verified Customer
My favorite hydrating cream. I recommend it to everyone who has sensitive skin. I have eczema and this helps my irritation so much.
Sima. • Verified Customer
A perfect moisturizer — also good under makeup and sunscreen.
Natalia. • Verified Customer
Read More Reviews
